1 Biochemistry
Biochemistry and Molecular Biology
Nucleic Acid Structure and Organization. 3
DNA Replication and Repair. 17
Transcription and RNA Processing. 31
The Genetic Code, Mutations, and Translation. 49
Genetic Regulation. 73
Recombinant DNA. 89
Genetic Testing. 103
Amino Acids, Proteins, and Enzymes. 127
Hormones. 143
Vitamins. 155
Overview of Energy Metabolism. 167
Glycolysis and Pyruvate Dehydrogenase. 175
Citric Acid Cycle and Oxidative Phosphorylation. 193
Glycogen, Gluconeogenesis and the Hexose Monophosphate Shunt. 205
Lipid Synthesis and Storage. 221
Lipid Mobilization and Catabolism. 241
Amino Acid Metabolism. 259
Purine and Pyrimidine Metabolism. 285
II. Medical Genetics
Single-Gene Diseases. 297
Population Genetics. 315
Cytogenetics. 323
Gene Mapping and Cloning. 337
Genetics of Common Diseases. 347
Genetic Diagnosis and Gene Therapy. 361
Immunology
Introduction. 373
Innate Immunity. 375
Acquired (Adaptive) Immunity. 383
Immunoglobulins and T-Cell Receptors. 387
Immunoglobulin and T-Cell Receptor (TCR) Genes. 397
Antigens and Immunogens. 405
Major Histocompatibility Complex (MHC). 407
The Lymphoid System. 413
Immune Response. 423
T-Cell Subsets and Interleukins. 433
X. Cell-Mediated Immunity. 439
Complement. 445
Failures of the Immune System: Hypersensitivity. 449
Failures of the Immune System: Immunodeficiency. 461
Failures of the Immune System: Autoimmunity. 467
Regulation and Tolerance. 471
Transplantation Immunology. 473
Immunology Laboratory Procedures. 475
Microbiology
General Microbiology 487
Medically Important Bacteria. 495
Medically Important Fungi. 607
Medical Parasitology. 623
Medically Important Viruses. 641
Microbial Genetics/Drug Resistance. 705
Clinical Infectious Disease. 741
Comparative Microbiology. 773
Appendix. Flow Charts/Clue Sheets. 789